Review of recent development in Anti-Markovnikov addition reaction of olefins

Abstract

The regioselective functionalization of terminal olefins is of significant importance in organic synthesis. Based on the critical observations of Markovnikov, the types of addition products can be identified as Markovnikov or anti-Markovnikov products. In recent years, the anti-Markovnikov addition reaction of olefins has caught many scientists’ eyes because of its broad application prospects in chemical and pharmaceutical industries and its perfectly compliant with green chemistry. Herein, we summarized the main methodologies developed for the functionalization of olefins and compared their advantages and disadvantages, hoping that this minireview can provide some inspiration for researchers to develop more effective pathways of functional group production based on olefins.