History And Artificial Synthesis Method of Tanshinone llA And Its Practical Application

Abstract

This work presents a comprehensive review of the history, artificial synthesis, and practical application of Tanshinone IIA, a compound primarily known for its anti-inflammatory properties. Tanshinone IIA suppresses the production of L-Arginine and the activation of inducible nitric oxide synthase (INOS), making it effective in treating inflammatory conditions. The synthesis of Tanshinone IIA involves multiple steps, including monomethylation, Friedel-Crafts bromination, halogenation, allylation, radical cyclization, and catalytic reduction, with 15-naphthalenediol serving as a cost-effective starting material. The artificial synthesis method provides advantages in terms of scalability and purity compared to traditional extraction. In addition, Tanshinone IIA is now incorporated into Danyi Tablets, a modern pharmaceutical used to treat prostatitis, which is increasingly prevalent among urban males. As traditional Chinese medicine evolves, this compound offers both therapeutic and economic benefits in the medical field.