Research Progress of Non-viral Vectors in Tumor Gene Therapy

Abstract

Gene therapy introduces genetic material cells to enhance or modify gene function and treat various diseases, including malignant tumors. However, due to poor resistance to degradation in vivo and difficulties in penetrating cell membranes, nucleic acid drugs need the help of vectors to enter target cells. Therefore, the development of safe and high-efficiency nucleic acid vectors is the key to gene therapy. Gene delivery vectors are mainly divided into two categories: viral and non-viral. The latter is concerned because of its low immunogenicity and high gene capacity. This article will summarize the research progress of common non-viral gene vectors in tumor gene therapy.