Targeted HIF-1a to Treat Tumors: Mechanisms, Application and Future

Abstract

Cancer has become one of the major health challenges in the world today. With the growth of population, the change of lifestyle and environmental pollution, the incidence of cancer is on the rise, which presents a major risk to the lives and health of people. At the same time, with the aging of the population and the change of lifestyle, the mortality rate of cancer continues to rise, which brings a heavy burden to society, families and individuals. At present, radiation therapy, chemotherapy, and surgical resection are the three primary cancer treatment methods.HIF-1a as a transcription factor is highly related to tumor proliferation, and related therapeutic strategies have great potential. This article provides an overview of the research on the relationship between HIF-1a and tumors, explains how HIF-1a can be used to stimulate tumor growth and stability, and lists some practical ways to use the HIF-1a transcription factor to treat tumors. It provides a new research direction reference and guidance for the frontier research of tumor therapy, and provides a new possible cure option for tumor patients.