Research Progress of PALB2 as a Susceptibility Gene for Breast Cancer

Abstract

Breast cancer is a complex disease that endangers women’s health worldwide. The research on breast cancer susceptibility genes is increasing, especially the newly discovered PALB2, which has aroused the enthusiasm of many researchers. At present, the correlation between PALB2 and breast cancer and the susceptibility of PABLB2 mutation to breast cancer has been a large number of clinical studies and clinical statistics around the world. PALB2 plays an important role in DNA homologous recombination repair (HRR) together with BRCA1 and BRCA2 in normal cells, and the mechanism of PALB2 mutation causing breast cancer is also related. The BRCA pathway inhibitor PARPi has also been well studied, but there is still room to study the specific resistance mechanism. In addition, PALB2 has been implicated in ovarian cancer, pancreatic cancer, and lung cell carcinoma. This provides a reference for the study of PALB2 in cancers other than breast cancer, and the role and mechanism of PALB2 can also be explored in more different cancers.