The Human Papillomavirus E6 Protein

Abstract

The association of human papillomavirus (HPV) infection with various forms of cancer, including oropharyngeal, cervical, and anal cancers, presents a significant global health concern. The HPV E6 oncoprotein plays a crucial role in promoting carcinogenesis by disrupting key cellular pathways involved in cell cycle control, apoptosis, and immune evasion. This review provides a comprehensive analysis of the molecular mechanisms by which HPV E6 induces cancer, with a particular focus on its association with cellular proteins and its role in the progression of malignancies associated with HPV. Additionally, therapeutic approaches targeting HPV E6 are discussed, including small molecule inhibitors, RNA interference strategies, and immunotherapies. These therapeutic modalities show promising potential for selectively targeting HPV-infected cancer cells and improving treatment outcomes for HPV-associated malignancies, particularly cervical cancer. Overall, understanding the molecular mechanisms driven by HPV E6 is essential for the development of targeted therapies and preventive strategies against HPV-induced cancers.