Enhanced mTORC1 Pathway Leads to Melanocyte Stem Cell AgingThrough DNA Damage
DOI:
https://doi.org/10.61173/v3yj7f36Keywords:
mTORC1, melanocyte stem cells, cell aging, DNA damage, hair grayingAbstract
The aging of skin stem cells is always attractive and highly relevant to our daily lives. Hair graying, mainly caused by
melanocyte stem cell (MeSC) aging, is a severe problem for many people. Previous studies have pointed out that DNA
damage is a significant reason for MeSC aging, and the enhanced mTORC1 pathway leads to DNA damage. Here,
experiments in vivo and in vitro were designed to verify that enhanced mTORC1 pathway leads to melanocyte stem
cell aging through the cause of DNA damage. The research could have the significance of discovering possible reasons
for hair graying and providing some new ideas in treating this abnormal divergence and other diseases relevant to cell
aging.
