Comparative Analysis of Icarrin and Curcumol as a Therapy for Pancreatic Cancer and Breast Cancer

Abstract

Breast cancer is the second most common type of cancer in American women. The incidence of pancreatic cancer has significantly risen over the past few decades. This study investigates whether icariin (ICA) and curcumin can show a more pronounced ability to inhibit tumor cell proliferation, induce apoptosis, and suppress cell migration and invasion in pancreatic and breast cancers. However, the specific impacts on different cancer types may vary. The objective of this research is to assess and compare the influence of ICA and curcumol on SNU-2466 pancreatic cancer cells and MCF7 breast cancer cells. The findings demonstrate that ICA and curcumol demonstrate a better effect on pancreatic cancer cells than in MCF7 breast cancer cells. Additionally, these compounds exhibit a stronger inhibitory effect on the PI3K/Akt/mTOR signaling pathway in pancreatic cancer cells compared to breast cancer cells. These results suggest that ICA and curcumol have more significant therapeutic potential in treating pancreatic cancer.