Association between three thyroid disruptors and sleep quality with the interacting role of vitamins and cholesterol

Abstract

Sleep quality is one critical indicator of human health and sleep-associated diseases are threatening the health condition of a significant proportion of the population. To resolve sleep disorder, many studies have explored on the effect of nutrient intake but few concentrated on the role of biochemical components within human’s body. Consequently, this study aims to explore the association of multiple biochemical components with sleep quality and therefore, contribute to future medications on sleep disorders. Data was extracted from NHANES 2017-2018 dataset and multiple models are constructed respectively to investigate the associations between perchlorate, nitrate, and thiocyanate exposures, and the risk of sleep disorder. Thiocyanate was observed to be significantly associated with sleep disturbance in both unadjusted (p=0.0278) and adjusted model (p=0.0421) while perchlorate (p=0.0257) and nitrate (p=0.0103) are merely significantly correlated with sleep disturbance in the adjusted model. Since causal relationships cannot be established, future studies are expected to explore underlying causal association and therefore, apply on medications targeting sleep disorders.