Investigating HLA-E Peptide Binding on Natural Killer Cells for Targeting Breast Cancer Stem Cells

Abstract

-Breast cancer stem cells (BCSCs) are a major challenge for many conventional therapies such as chemotherapy and radiotherapy. Natural killer cells are often mentioned in immunotherapy, but the need for activation makes NK cell immunotherapy less than satisfactory. Recent studies have found that the MHC HLA-E protein has an abundant peptide expression that can activate NK cells. This study will focus on using HLA-E-expressed peptides in MHC proteins to activate NK cells and develop new possibilities for immunotherapy.