Identifying the role of circRNAs in the interaction with miRNAs during the limb regeneration in axolotl

Abstract

The current literature lacks a comprehensive assessment of circular RNA’s role in the limb regeneration in the axolotl model, which has become the foundation for recent investigations into this topic. This paper aims to address this important gap by presenting a detailed overview and reassessment of circular RNA’s potential implications in the context of axolotl limb regeneration, particularly in relation to the interaction with miRNAs. Moreover, this paper shows the utility and significance of the axolotl model organism as a valuable resource for the study of limb regeneration mechanisms. Furthermore, the study delves into the methodology and theoretical underpinnings behind the identification and mapping of circular functional genes, which is an integral step in understanding their specific contributions to the process of limb regeneration. The outcomes of this research could probably provide a solid foundation for future studies on limb regeneration, as well as a deeper understanding of the complex regulatory mechanisms that underlie this biological process.