STAT3 and the resistance ability of HSC to ionizing radiation

Abstract

HSC is a very important part of the blood system and has a functional transcription factor, STAT3. When STAT3 is damaged, it is very likely to lead to death of HSC and even the whole organism. The ionizing radiation, on the other hand, is ubiquitous in the universe and is sure to cause damage to HSC. There is no doubt that the ionizing radiation damage to STAT3 is a big obstacle we need to overcome in our journey to explore space. Thus, in this work we will use the bone marrow hematopoietic stem cells of mice to further study the regulation pathway between STAT3 and the resistance ability of HSC to ionizing radiation.