Gene Expression Differences and Similarities between Bipolar Disorder and Gliomas Studied by Brain Expression Data

Abstract

Both bipolar disorder and glioma are highly prevalent diseases. Bipolar disorder is a significant mental illness, while glioma constitutes 46% of intracranial tumors. By conducting differential expression analysis, Weighted Gene Coexpression Network Analysis, and Gene Ontology enrichment analysis on brain expression data of bipolar disorder and glioma, it was found that these two conditions share three terms: protein localization to organelle, organelle localization, and protein maturation. Exploring targeted therapy and drug-targeting research on these three terms can offer novel insights for the treatment of both bipolar disorder and glioma.