ZNF292, Breast cancer, Tumor Suppressor Gene, Gene Expression
Abstract
Breast cancer as one of the most malignant tumors in the world numbered sixth in all cancer-related deaths. In China, breast cancer has become one of the most seriously fatal malignant tumors. Etiologically, breast cancer can be classified as basal-like breast cancer (BLBC), of which about ninety percent of BLBC patients are Chinese. The absence of precise mechanisms underlying the pathogenesis and aggressive progression of BLBC has greatly hindered the search for effective targeted therapeutic agents. Therefore, the search for better intervention and therapeutic options in terms of molecular mechanisms is an excellent approach. There is growing evidence that ZNF292 has an inhibitory role in cancer, but its function and exact mechanism in breast cancer are unknown. This paper explores the impact of ZNF292 on breast cancer by combining important findings on the role of ZNF292 in cancer over the past year, and the results of taz-driven human breast cancer via inhibition of SKP2- P27 targeting.
