A metabolic condition called hyperuricemia (HUA) is intimately linked to the beginning and development of numerous chronic illnesses. Increased blood levels of uric acid (UA), or hyperuricemia, are indicative of a higher risk of developing gout and other metabolic problems. Probiotics have been shown to have positive impacts on human health regulation in recent years. These effects include a significant contribution to the control of conditions including type 2 diabetes, obesity, hypertension, and human immunity. Furthermore, pertinent research conducted in the last several years has discovered that probiotics can somewhat alleviate HUA. The use of probiotics for the prevention and treatment of hyperuricemia is discussed in this paper along with the current status of research in this area. Probiotics work by modulating urate metabolism, attenuating inflammatory responses, and improving related metabolic parameters. Additionally, clinical trials assessing the efficacy of specific probiotic strains or blends in reducing serum UA concentrations are included in the analysis, indicating that probiotics could be a future focus for the prevention of hyperuricemia. However, the optimal dose and duration of probiotic supplementation remains to be determined and clinical trials on human subjects should be further expanded. To ascertain the long-term safety and effectiveness of probiotics as an adjuvant treatment for HUA and associated comorbidities, more research is required.
