Current studies have revealed that the stem cells of various animal species exhibit high levels of ionizing radiation, which is a phenomenon that requires further investigation to fully understand its underlying mechanisms. It is well established that antioxidants can protect organisms from radiation damage primarily by inactivating free radicals. Therefore, we propose the bold hypothesis that antioxidants are the primary contributors to the radiation tolerance of animal stem cells. To test this hypothesis, we plan to use Eisenia Fetida as a model organism to identify the potential antioxidant enzymes and proteins within its cells, then investigate whether these molecules are crucial factors in the overall radiation resistance of the organism. The conclusions drawn from this hypothesis could contribute to a broader theoretical framework in the field and benefit future research efforts.