Tumor Suppressor Gene VHL, Mechanism and Related Therapy

Authors

  • Dongrui Shi Author

DOI:

https://doi.org/10.61173/tgh4jv76

Keywords:

Von Hippel-Lindau syndrome, VHL gene, tumor suppressor gene, tumorigenesis, angiogenesis, oxygen sensing, VHL-related tumors, VHL gene mutations, targeted therapies, surgical interventions, radiotherapy

Abstract

Von Hippel-Lindau (VHL) syndrome is a rare hereditary disorder characterized by the development of multiple tumors
in various organs. This paper provides a comprehensive overview of the VHL gene, its mechanism of action, and its
implications in VHL-related tumorigenesis. The first section explores the role of the VHL tumor suppressor gene in
regulating angiogenesis and oxygen sensing, highlighting its significance in tumor suppression. The second section
discusses the association between VHL gene mutations and the development of various tumor types, emphasizing the
diverse clinical manifestations of VHL syndrome. The third section examines the diagnostic methods for identifying
VHL gene mutations, including genetic testing and clinical evaluations. The fourth section delves into therapeutic
approaches for managing VHL-related tumors, encompassing surgical interventions, targeted therapies, radiotherapy,
and emerging treatment strategies. This paper aims to enhance understanding of VHL syndrome, facilitate early
diagnosis, and guide treatment decisions for individuals affected by this complex disorder.

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Published

2023-08-01

Issue

Section

Articles