The Connection Between Circadian Disruption and Cancer Risks

Abstract

The circadian rhythm is an essential biological mechanism that uses the 24-hour geophysical cycle to regulate the
body’s physiological and behavioral processes. It operates on a complex molecular interaction system that coordinates
gene expression, protein synthesis, and post-translational modifications. Disruption of this rhythm due to jet lag, shift
work, and other unhealthy lifestyles has been linked to various health disorders, including cancer. Recent studies have
suggested a strong association between circadian disruption and development cancers, such as breast cancer, lung
cancer, and glioblastoma. Understanding the connection between circadian disruption and cancer and the mechanisms
underlying this connection is essential for developing new cancer therapies. In this review, we provide an updated
account of key circadian mechanisms and their regulations on human health. We examine the adverse impact of
circadian disruption on health using lung cancer and glioblastoma as case studies. Finally, we also discuss the potentially
promising cancer treatment of chronotherapy, which targets components of the circadian cycle. We believe that future
research into circadian rhythm and cancer would encourage the progression into a new era of cancer medicine.