Anti-inflammatory response controlled by gamma wave

Abstract

Since recognized as an important factor in Alzheimer’s disease, microglia are often found to shift from a neuroprotective M2 phenotype to a pro-inflammatory M1 phenotype thus cause neuroinflammation. This research proposal aims to put forward a new therapy in treating Alzheimer’s disease, in specific, by modulating gamma wave frequency and thereby regulate the polarization state of microglia. If it changes from M1 to M2, it changes from pro-inflammatory to anti-inflammatory, which means this strategy is efficient in treating Alzheimer’s disease.