Basics of Retrosynthetic Analysis: A Review for Beginners

Abstract

Retrosynthesis in organic chemistry seeks a possible way to synthesize a complex organic molecule by considering the reverse synthesis route. Chemists can explore multiple possibilities and find the most efficient synthesis route by starting from the target molecule and returning to simple reactants. This work is an essential guide for doing retrosynthesis analysis by providing examples and explanations of the fundamental notions and procedures involved. We will discuss topics like bond disconnections, FGIs, and synthons. This work illustrates the retrosynthesis analysis of complicated organic molecules using the discussed principles and methods.