Substance abuse remains a critical public health issue in the U.S., with rising overdose rates affecting both adolescents and older adults. Despite the growing impact on these age groups, there is a gap in research exploring the distinct factors that drive substance abuse across generations, particularly among older adults, who remain underrepresented in clinical studies. This essay aims to compare the current situation and psychological, social, and policy-related drivers of substance abuse between adolescents and older adults, while proposing age-specific interventions to address these issues. Using a literature review and data analysis from national health surveys and clinical research, key findings suggest that adolescents are increasingly vulnerable to synthetic opioids like fentanyl, while older adults face challenges related to polypharmacy, chronic pain, and inadequate healthcare access. Consequently, this essay emphasizes the need for distinct prevention and treatment methods, calling for more inclusive research on older adults though advancing public health policies, improved access to addiction treatment by expanding practitioner workforce, and the use of digital health tools to provide age-appropriate care in the future.
